2003年以来发表的主要论文：
1.Zhou F, Yao HH, Wu JY, Sun XL, Ding JH, Hu G. Opening of microglial KATP channels inhibits rotenone-induced neuroinflammation. Journal of Cellular and Molecular Medicine, 2007; Accepted
2.
Xiu-Lan Sun, Xiao-Ning Zeng, Fang Zhou1, Cui-Ping Dai, Jian-Hua Ding and Gang Hu. KATP Channel Openers Facilitate Glutamate Uptake by GluTs in Rat Primary Cultured Astrocytes. Neuropsychopharmacology. 2007 Jul 4; [Epub ahead of print]
3.
Zhou F, Wu JY, Sun XL, Yao HH, Ding JH, Hu G. Iptakalim Alleviates Rotenone-Induced Degeneration of Dopaminergic Neurons through Inhibiting Microglia-Mediated Neuroinflammation. Neuropsychopharmacology. 2007 Mar 14; [Epub ahead of print]
4.
Zhang S, Zhou F, Ding JH, Zhou XQ, Sun XL, Hu G. ATP-sensitive potassium channel opener iptakalim protects against MPP(+)-induced astrocytic apoptosis via mitochondria and mitogen-activated protein kinase signal pathways. J Neurochem. 2007 Oct;103(2):569-79.
5.
Fan Y, Kong H, Shi X, Sun X, Ding J, Wu J, Hu G. Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation. Neurobiol Aging. 2007 Mar 10; [Epub ahead of print]
6.
Xiao-Ning Zeng, Xiu-Lan Sun, Lin Gao, Yi Fan, Jian-Hua Ding, Gang Hu. Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes. Molecular and Cellular Neuroscience, 2007；34：34-39
7.
Xiu-Lan Sun, Jian-Hua Ding , Yi Fan, Jing Zhang, Lin Gao, Gang Hu. Aquaporin 4 regulates the effects of ovarian hormones on monoamine neurotransmission. Biochem? Biophys Res Comm 2007; 353: 457–462.
8.
Hua X, Lei M, Zhang Y, Ding J, Han Q, Hu G, Xiao M.? Long-term D-galactose injection combined with ovariectomy serves as a new rodent model for Alzheimer's disease. Life Sci. 2007 Apr 24;80(20):1897-905.
9.
Yang J, Campitelli J, Hu G, Lin Y, Luo J, Xue C. Increase in DPP-IV in the intestine, liver and kidney of the rat treated with high fat diet and streptozotocin. Life Sci. 2007 Jul 4;81(4):272-9.
10.
Yi Chai; Ling Niu; Xiu-Lan Sun; Jia-Hua Ding，Gang Hu. Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel. Biochem Biophys Res Comm， 2006；350（2）：307-314
11.
Wang S, Hu LF, Zhang Y, Sun T, Sun YH, Liu SY, Ding JH, Hu G. Effects of Systemic administration of iptakalim on extracellular neurotransmitter levels in the striatum of unilateral 6-hydroxydopamine-Lesioned rats? Neuropsychopharmacology, 2006; 31(1):933-40.
12.
Zhou F, Yao HH, Wu JY, Ding JH, Hu G Activation of Group II/III Metabotropic Glutamate Receptors Attenuates LPS-induced Astroglial Neurotoxicity via Promoting Glutamate Uptake. Journal of Neuroscience Research, 2006;84(2):268-77.
13.Yang Y, Liu X, Long Y, Wang F, Ding JH, Liu SY, Sun YH, Yao HH, Wang H, Wu J, Hu G. Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats. Int J Neuropsychopharmacol， 2006；9(1):51-61.
14.
Hu J, Hu G, Wang H, Lukas RJ, Wu J. Iptakalim as a human nicotinic acetylcholine receptor antagonist. J Pharmacol Exp Ther，2006; 316: 914-25.
15.
Yang J, Hu LF, Liu X, Zhou F, Ding JH, Hu G. Effects of iptakalim on extracellular glutamate and dopamine levels in the striatum of unilateral 6-hydroxydopamine-lesioned rats: A microdialysis study. Life Sciences， 2006；78（17）:1940-1944.
16.Liu X, Wu JY, Zhou F, Sun XL, Yao HH, Yang Y, Ding JH, Hu G. Regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channels expressed in BV-2 cells. Neuroscience Letter, 2006; 394(2 ):131-5.
17.Liu Q, Li Z, Ding JH, Wu J, Hu G. Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats. Brain Research. 2006; 1085：138-43.
18.
Chen H, Yang Y, Yao HH, Tang XC, Ding JH, Wang H, Hu G.. Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbils. Acta Pharmacol Sin， 2006;27(6):665-72.
19.
Liu Y, sun WL, Sun Y, Ding GX, Hu G. Role of 11-β-hydroxysteroid dehydrogenase type 1 in differentiation of 3T3-L1 cells and in rats with diet-induced obesity. Acta Pharmacol Sin，2006;27(5):588-96.
20.Cao C, Sun Y, Bi Z, Hu G, Wan S, Chu W, Wan Y. EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration. Biochem J. 2006 Jul 19; [Epub ahead of print]
21.
Wu J, Hu J, Chen YP, Takeo T, Suga S, Dechon J, Liu Q, Yang KC, St John PA, Hu G. Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta. J Pharmacol Exp Ther. 2006 Oct;319(1):155-64.
22.Zhang B, Liu JY, Pan JS, Han SP, Yin XX, Wang B, Hu G. Combined Treatment of Ionizing Radiation With Genistein on Cervical Cancer HeLa Cells. J Pharmacol Sci. 2006; 102(1):129-35.
23.
Li L, Ding J, Ren Z, Han Q, Hu G, Xiao M. Expression and colocalization of NADPH-diaphorase and Fos in the subnuclei of the parabrachial nucleus in rats following visceral noxious stimulation. Brain Res. 2006; 1038:150-62.
24.
Li Z, Gao L, Liu Q, Cao C, Sun XL, Ding JH, Hu G. Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice. Neurosci Lett. 2006;403(3):294-8.
25.
Yang YJ, Wang QM, Hu LF, Sun XL, Ding JH, Hu G. Iptakalim alleviated the increase of extracellular dopamine and glutamate induced by 1-methyl-4-phenylpyridinium ion in rat striatum. Neurosci Lett. 2006; 404(1-2):187-90.
26.
Chen ZY, Xie HT, Zheng QS, Sun RY, Hu G. Pharmacokinetic and pharmacodynamic population modeling of orally administered rabeprazole in healthy Chinese volunteers by the NONMEM method.? Eur J Drug Metab Pharmacokinet. 2006; 31(1):27-33.
27.
Hu J, DeChon J, Yan KC, Liu Q, Hu G, Wu J. Iptakalim inhibits nicotinic acetylcholine receptor-mediated currents in dopamine neurons acutely dissociated from rat substantia nigra pars compacta. Neurosci Lett. 2006;403(1-2):57-62.
28.
Zhu H, Yang L, Zhou B, Yu R, Tang N, Wang B. Myeloperoxidase G-463A polymorphism and the risk of gastric cancer: a case-control study. Carcinogenesis. 2006 Dec; 27(12):2491-6.
29.
Zhang B, Pan JS, Liu JY, Han SP, Hu G, Wang B. Effects of chemotherapy and/or radiotherapy on survivin expression in ovarian cancer. Methods Find Exp Clin Pharmacol. 2006 Nov; 28(9):619-25.
30.Zhang B, Liu JY, Pan JS, Han SP, Yin XX, Wang B, Hu G. Combined treatment of ionizing radiation with genistein on cervical cancer HeLa cells. J Pharmacol Sci. 2006 Sep; 102(1):129-35.
31.
Zhou B, Wang B. Pegaptanib for the treatment of age-related macular degeneration. Exp Eye Res. 2006 Sep; 83(3):615-9.
32.
Pan JS, Zhu HJ, Zhang B, Li H, Yan H, Wang B. Inhibitive effect of genistein on hypoxia-induced basic fibroblast growth factor expression in human retinal pigment epithelium cells. J Ocul Pharmacol Ther. 2006 Apr; 22(2):103-9.
33.
Chen L, Yamada K, Nabeshima T, Sokabe M. 7 nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP in βamyloid infused rats. Neuropharmacology, 2006; 50:254-268.
34.
Chen L, Dai X, Sokabe M. Chronic adminstration of DHEAS primes for facilitation induction of long-term potentiation via sigma 1 ( 1) receptor: optical imaging study in rat hippocampal slices. Neuropharmacology , 2006; 50:380-392.
35.
Chen L, Miyamoto Y, Mori N, Sokabe M. Chronic DHEAS administration facilitates hippocampal long-term potentiation via an amplification of Src-dependent NMDA receptor signaling. (2006) Neuropharmacology, 2006; 50:880-892.
36.
Li Z, Zhou R, Cui SZ, Xie GQ, Sokabe M, Chen L. Neurosteroid DHEAS exerts protective effects against ischemic deficit in hippocampal LTP via tyrosine phosphorylation of NMDA receptor. Neuropharmacology, 2006; 51:958-966.
37.
Li Z, Zhou R, Cui SZ, Xie GQ, Sokabe M, Chen L. Administration timing is critical for the neuroprotection and neurotoxicity of DHEA in the hippocampus subjected to transient global ischemia. Stroke, 2007 May 14; [Epub ahead of print]
38.
Hu LF, Wang S, Shi XR, Yao HH, Sun YH, Ding JH, Hu G. ATP-sensitive potassium channel opener iptakalim protected against the cytotoxicity of MPP+ on SH-SY5Y cells by decreasing extracellular glutamate level. Journal of Neurochemistry, 2005; 94(6):1570-9.
39.
Fan Y, Zhang J, Sun XL, Gao L, Zeng XN, Ding JH, Cao C, Niu L, Hu G. Sex- and region-specific alterations of basal amino acid and monoamine metabolism in the brain of aquaporin-4 knockout mice. Journal of Neuroscience Research, 2005; 82(4): 458-64.
40.
Wu J, Wang H, Hu G. ATP-sensitive potassium channel openers and Neuronal Protection. Current Neuropharmacology, 2005; 3（3）:249-56.
41.
Yang Y, Liu X, Long Y, Wang F, Ding JH, Liu SY, Sun YH, Yao HH, Wang H, Wu J, Hu G. Systemic administration of iptakalim prevents rotenone-induced motor and neurochemical alterations in rats. Journal of Neuroscience Research 2005；80(3):442-9.
42.
Wang S, Hu LF, Yang Y, Ding JH, Hu G. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson’s disease：Implications for treating Parkinson’s disease Neuropharmacology，2005; 48(7):984-92.
43.
Yao HH, Ding JH, Zhou F, Wang F, Hu LF, Sun T, Hu G. Enhancement of glutamate uptake mediates the neuroprotection exerted by activating group II or III metabotropic glutamate receptors on astrocytes. Journal of Neurochemistry， 2005; 92(4):948-61.
44.
Yang YL, Meng CH, Ding JH, He HR, Ellsworth K, Wu J, Hu G. Iptakalim hydrochloride protects cells against neurotoxin-induced glutamate transporter dysfunction in in vitro and in vivo models. Brain Research, 2005;1049(1):80-8.
45.
Xiao M, Ding J, Wu LX, Han QY, Wang HM, Zuo GP, Hu G. The distribution of neural nitric oxide synthase-positive cerebrospinal fluid-contacting neurons in the third ventricular wall of male ratsand coexistence with vasopressin or oxytocin. Brain Research，2005；1038：150–62.
46.
Yin X, Cui W, Hu G, Wang H. Desensitization of alpha7 nicotinic receptors potentiated the inhibitory effect on M-current induced by stimulation of muscarinic receptors in rat superior cervical ganglion neurons. Journal of Neural Transmission，2005;112(9):1133-48.
47.
Xie WP, Wang H, Ding JH, Wang, Hu G. Anti-proliferating effect of iptakalim, a novel K-ATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells Eur J Pharmacol, 2005; 511(2-3):81-7.
48.
Zhang J, Hu J, Ding JH, Yao HH, Hu G. 6-Hydroxydopamine-induced glutathione alteration occurs via glutathione enzyme system in primary cultured astrocytes. Acta Pharmacol Sin，2005 ; 26(7):799-805.
49.
Wang H, Zhang YL, Tang XC, Feng HS, Hu G. Targeting Ischemic Stroke with a Novel Opener of ATP-Sensitive Potassium Channels in the Brain. Molecular Pharmacology, 2004; 66: 1160–8.
50.
Xie W, Wang H, Wang H, Hu G. Effects of iptakalim hydrochloride, a novel K-ATP channel opener, on pulmonary vascular remodeling in hypoxic rats. Life Sciences，2004; 75(17): 2065-76.
51.
Yang Y, Liu X, Ding JJ, Sun J, Long Y, Wang F, Yao HH, Hu G. Effects of iptakalim on rotenone-induced cytotoxicity and dopamine release from PC12 cells. Neuroscience Letter, 2004; 366: 53–57.
52.
Yu M, Chen DM, Hu G, Wang H. Proteomic response analysis of endothelial cells of human coronary artery to stimulation with carbachol. Acta Pharmacol Sin，2004; 25(9):1124-30.
53.
Sun X, Liu Y, Hu G, Wang H. Activities of cAMP-dependent protein kinase and protein kinase C are modulated by desensitized nicotinic receptors in the rat brain. Neurosci Lett，2004; 367(1):19-22.
54.
Xiulan Sun, Yue Liu, Gang Hu, Hai Wang. Protective effects of nicotine against glutamateinduced neurotoxicity in PC12 cells. Cellular & Molecular Biology Letters. 2004; 9:409-22.
55.
Yao HH, Ding JH, Hu G. Inhibitory effects of 1-methyl-4-phenylpyridinium on the glutamate uptake into cultured C6 glioma cells. Acta Pharmacol Sin, 2004; 25(7): 855-60.
56.
Gu B, Zhang YD, Hu G. A unilateral 6-hydroxydopamine lesion decreases the expression of metabotropic glutamate receptors in rat substantia nigra. Neurosci Lett，2003; 351(3):186-90.
57.
Liu Y, He HR, Ding JH, Gu B, Wang H, Hu G. Iptkalim inhibits cocaine challenge-induced enhancement of dopamine levels in nucleus accumbens and striatum of rats by increasing Kir6.1 and Kir6.2 mRNA expression. Acta Pharmacol Sin， 2003; 24(6): 619-23.
58.
Li H, Ding JH, Hu G. Group Ⅰ mGluRs ligands fail to affect6-hydroxydopamine-induced death and glutamate release of PC12 cells. Acta Pharmacol Sin， 2003; 23（5）: 524-8.
59.
Hu Q, Ding JH, Liu SY, Li P, Hu, G. Pharmacokinetics of magnesium glycyrrhizinate following intravenous administration of magnesium glycyrrhizinate in rats. Eur J Drug Metab Pharmacokinet，2003; 28(4): 259-64.
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