| 苗登顺 男,1954年生,博士、特聘教授、博士生导师,Journal of Bone and Mineral Research、Endocrinology、British Journal of Cancer、Biotechnology Progress和Toxicology and Applied Pharmacology杂志审稿人,南京医科大学解剖学系学术带头人,骨与干细胞研究中心主任,加拿大McGill大学医学系兼职教授。博士毕业于英国Sheffield大学,博士后训练在加拿大的 McGill大学完成,师从David Goltzman教授(加拿大皇家院士)。2002至2005年在加拿大McGill大学担任助理教授。2005年5月归国。在过去的5年中,发表SCI收录的英文全文著作32篇,累计影响因子超过200,引用近500次;SCI收录的英文会议摘要32篇,参编英文论著两部。苗登顺教授利用不同的甲状旁腺素,甲状旁腺素相关肽及25-1α-羟化酶等基因敲除动物模型进行骨与干细胞生物学方面的研究。在相关领域的研究中,其研究水平目前处于国际领先地位。
获奖情况
1994 江苏省普通高校优秀青年骨干教师
1995.1-1996.1 英国皇家协会信托奖学金
1996.1-1999.1 英国sheffield大学奖学金
1999.7-2002.6 加拿大国立卫生研究院职业奖学金
2001.10 美国骨与矿物质研究青年学者奖
2002-2005 蒙特利尔总医院175周年奖学金
承担项目和在研资金情况
2006.9-2009.9 国家自然科学基金30万
2005.5 南医大人才引进启动资金200万元
2005.9-2008.9 国家重点学科培育点200万元
2002.7-2005.6 钙调激素在促进骨形成中的作用机制。蒙特利尔总医院科研基金。17.5万加币。
2002.7-2004.6 维生素D和PTH在调节骨代谢和钙离子平衡中的相互作用。加拿大国立卫生研究院。11.5万加币.
近五年发表的英文论文
- Miao D, He B, Jiang YB, Kobayashi T, Sorocéanu ?MA, Tong XK, Su HY, Amizuka N, Gupta A, Genant HK, Kronenberg HM, Goltzman D, Karaplis AC. 2005. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin. Invest. 115 (9):2402-2411. (IF=14.204)
- Xue YB, Karaplis AC, Hendy GN, Goltzman D, Miao D (Senior Author). 2005. Genetic Models Show That Parathyroid Hormone and 1,25-Dihydroxyvitamin D3 Play Distinct and Synergistic Roles in Postnatal Mineral Ion Homeostasis and Skeletal Development. Hum Mol Genetics. 14(11):1515-1528. (IF=7.801)
- Xue YB, Zhang ZL, Karaplis AC, Hendy GN, Goltzman D, Miao D (Senior Author). 2005. Exogenous Parathyroid Hormone-related Protein Rescues?? 25-Hydroxyvitamin D 1α-Hydroxylase and Parathyroid Hormone Double Knockout Mice. J Bone Miner Res. 20 (10):1766-1777. (IF=5.436)
- ?Sun, L.Q., D.W. Lee, Q. Zhang, W. Xiao, E.H. Raabe, A. Meeker, D. Miao, D.L. Huso, and R.J. Arceci. 2004. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev 18:1035-1046. (IF=16.385)
- Shin, H.I., P. Divieti, N.A. Sims, T. Kobayashi, D. Miao, A.C. Karaplis, R. Baron, R. Bringhurst, and H.M. Kronenberg. 2004. Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology 145:1376-1385. (IF=5.151)
- Panda, D.K., D. Miao (Co-first author), I. Bolivar, J. Li, R. Huo, G.N. Hendy, and D. Goltzman. 2004. Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem 279:16754-16766. (IF=6.482)
- Miao, D., S. Murant, P. Genever, and A. Scutt. 2004. Megakaryocyte/bone marrow stromal cell aggregates demonstrate increased osteogenic capacity in vitro. Tissue Engineering 10:807-817. (IF=3.143)
- Miao, D., B. He, B. Lanske, X.Y. Bai, X.K. Tong, G.N. Hendy, D. Goltzman, and A.C. Karaplis. 2004. Skeletal abnormalities in Pth-null mice are influenced by dietary calcium. Endocrinology 145:2046-2053. (IF=5.151)
- Miao, D., H. Liu, P. Plut, M. Niu, R. Huo, D. Goltzman, and J.E. Henderson. 2004. Impaired endochondral bone development and osteopenia in Gli2-deficient mice. Exp Cell Res 294:210-222. (IF=4.007)
- Miao, D., X. Bai, D.K. Panda, A.C. Karaplis, D. Goltzman, and M.D. McKee. 2004. Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice. Bone 34:638-647. (IF=3.530)
- Miao, D., J. Li, Y. Xue, H. Su, A.C. Karaplis, and D. Goltzman. 2004. Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice. Endocrinology. 145 (8): 3554-3562. (IF=5.151)
- Goltzman, D., D. Miao, D.K. Panda, and G.N. Hendy. 2004. Effects of calcium and of the Vitamin D system on skeletal and calcium homeostasis: lessons from genetic models. J Steroid Biochem Mol Biol 89-90:485-489. (IF=2.715)
- Soroceanu MA, Miao D, Bai XY, Su H, Goltzman D, Karaplis AC. 2004. Rosiglitazone Impacts Negatively on Bone Mineral Density. J Endocrinology ??183(1):203-216. (IF=3.319)
- Bai X, Miao D, Li J, Goltzman D, Karaplis AC. 2004. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate. Endocrinology? 145(11):5269-5279. (IF=5.151)
- Thomas, G., P. Moffatt, P. Salois, M.H. Gaumond, R. Gingras, E. Godin, D. Miao, D. Goltzman, and C. Lanctot. 2003. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. J Biol Chem 278:50563-50571. (IF=6.482)
- Chan, G.K., D. Miao, R. Deckelbaum, I. Bolivar, A. Karaplis, and D. Goltzman. 2003. Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells. Endocrinology 144:5511-5520. (IF=5.151)
- Bai, X.Y., D. Miao (Co-first author), D. Goltzman, and A.C. Karaplis. 2003. The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency. J Biol Chem 278:9843-9849. (IF=6.482)
- Miao, D., and A. Scutt. 2002. Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage. J Histochem Cytochem 50:333-340. (IF=2.513)
- Miao, D., and A. Scutt. 2002. Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo. BMC Musculoskelet Disord 3:16.
- ?Miao, D., B. He, A.C. Karaplis, and D. Goltzman. 2002. Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109:1173-1182. (IF=14.204)
- Deckelbaum, R.A., G. Chan, D. Miao, D. Goltzman, and A.C. Karaplis. 2002. Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA. J Cell Sci 115:3015-3025. (IF=6.910)
- Bai, X., D. Miao (Co-first author), D. Panda, S. Grady, M.D. McKee, D. Goltzman, and A.C. Karaplis. 2002. Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Mol Endocrinol 16:2913-2925. (IF=5.872)
- Panda, D.K., D. Miao (Co-first author), M.L. Tremblay, J. Sirois, R. Farookhi, G.N. Hendy, and D. Goltzman. 2001. Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci U S A 98:7498-7503. (IF=10.452)
- Panda, D.K., D. Miao, V. Lefebvre, G.N. Hendy, and D. Goltzman. 2001. The transcription factor SOX9 regulates cell cycle and differentiation genes in chondrocytic CFK2 cells. J Biol Chem 276:41229-41236. (IF=6.355)
- Miao, D., X. Bai, D. Panda, M. McKee, A. Karaplis, and D. Goltzman. 2001. Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition. Endocrinology 142:926-939. (IF=5.151)
- Miao, D., X.K. Tong, G.K. Chan, D. Panda, P.S. McPherson, and D. Goltzman. 2001. Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem 276:32204-32213. (IF=6.355)
- He, B., R.A. Deckelbaum, D. Miao, M.L. Lipman, M. Pollak, D. Goltzman, and A.C. Karaplis. 2001. Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles. Endocrinology 142:2070-2077. (IF=5.151)
近年参编著作
1.Miao D, He B, Lanske B, Bai XY, Tong XK, Hendy GN, Goltzman D and?? Karaplis AC. Skeletal and reproductive abnormalities in pth-null mice. In: Molecular Biology of the Parathyroid. Naveh-Many, Tally (Ed.). 2005:179-197.
2.D. Goltzman, D. Miao. Alkaline phosphatase. M. L, Ed., the Encyclopedia of Endocrine Diseases Academic Press/Elsevier, San Diego. 2004; 164-169
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