沙家豪博士，国家杰出青年基金承担者，江苏省生殖医学重点实验室主任，江苏省政协常务委员，全国优秀教师。长期从事生殖医学研究，主要研究领域包括男性抗生育及配子发生的机理研究。学术团体任职：中国动物学会生殖生物学分会副理事长、中国解剖学会江苏分会副理事长、中华医学会生殖医学分会常委 、中华医学会医学细胞生物学会理事、《生殖医学杂志》常务编委、《国外医学计划生育分册》常务编委、《中国男科杂志》编委、《男科学报》编委、《中国计划生育学杂志》编委。

 

主要研究方向：

       男性抗生育

       配子发生机理

 

目前主持承担的主要科研项目：

国家杰出青年基金：NYD-SPn基因功能的研究

国家自然科学基金重点项目：人类睾丸蛋白质的表达及功能研究

国家重点基础研究规划973项目课题：睾丸中精子功能相关蛋白与疾病

重大基础研究前期研究专项：NYD-SPn基因功能的研究

 

近年来发表的文章（IF≥3.0）：

1. Zhao C, Huo R, Wang FQ, Lin M, Zhou ZM, Sha JH. Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril. 2006 Oct 27; [Epub ahead of print]
2. Zhu YF, Cui YG, Guo XJ, Wang L, Bi Y, Hu YQ, Zhao X, Liu Q, Huo R, Lin M, Zhou ZM, Sha JH. Proteomic analysis of effect of hyperthermia on spermatogenesis in adult male mice. J Proteome Res. 2006 Sep;5(9):2217-25
3. Du Y, Huang XY, Li JM, Hu YQ, Zhou ZM, Sha J. Human testis specific protein 1 expression in human spermatogenesis and involvement in the pathogenesis of male infertility. Fertil Steril 2006;85(6):1852-1854
4. Hu YQ, Lu Y, Zhou ZM, Du Y, Xing J, Wang L, Lin M, Sha JH. Defective expression of Galpha12 in the testes of azoospermia patients and in the spermatozoa with low motility. J Mol Med. 2006 May;84(5):416-424
5. Wang L, Zhu YF, Guo XJ, Huo R, Ma X, Lin M, Zhou ZM, Sha JH. A two-dimensional electrophoresis reference map of human ovary. J Mol Med 2005;83:812-821
6. Huang XY, Zhang J, Lu L, Yin LL, Xu M, Wang YQ, Zhou ZM, Sha JH. Cloning and expression of a novel CREB mRNA splice variant in human testis. Reproduction 2004;128:775–782
7. Diao FY, Xu M, Hu YQ, Li JM, Xu ZY, Lin M, Wang LR, Zhou YD, Zhou ZM, Liu JY, Sha JH. The molecular characteristics of olycystic ovary syndrome (PCOS) ovary defined by human ovary cDNA microarray. Journal of Molecular Endocrinology 2004;33: 59–72
8. Wang H, Xu M, Li JM, Xiao JH, Xu ZY, Zhou ZM, Sha JH. A Spermatogenesis-related gene expression profile in Human Spermatozoa and Its Potential Clinical Application.? Journal of Molecular Medicine 2004; 82:317-324
9. Zhu H, Zhu JX, Lo PS, Li J, Leung KM, Rowlands DK, Tsang LL, Yu MK, Jiang JL, Lam SY, Chung YW, Zhou ZM, Sha JH, Chang Chan H. Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C. Lancet 2003;362:2059-2065
10. Xu M, Xiao JH, Chen J, Li JM, Yin LL, Zhu H, Zhou ZM, Sha JH. Identification and characterization of a novel human testis-specific Golgi protein, NYD-SP12. Molecular Human Reproduction 2003;9(1):9-17
11. Cheng LJ, Li JM, Chen J, Ge YH, Yu ZR, Han DS, Zhou ZM, Sha JH. NYD-SP16, a novel gene associated with spermatogenesis of human testis. Biology of Reproduction. 2003;68(1):190-198
12. Sha JH, Zhou ZM, Li JM, Yin LL, Yang HM, Hu GX, Luo M, Chan HC, Zhou KY. Identification of development/spermatogenesis-related genes in human and mouse testes using cDNA arrays.? Molecular Human Reproduction 2002; 8(6):511-517